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- Title
The role of baseline Ga-68 DOTATATE positron emission tomography/computed tomography in the prediction of response to fixed-dose peptide receptor radionuclide therapy with Lu-177 DOTATATE.
- Authors
SOYDAL, Çiğdem; PEKER, Ahmet; ÖZKAN, Elgin; KÜÇÜK, Özlem Nuriye; KIR, Metin Kemal
- Abstract
Background/aim: radionuclide To describe the role of baseline gallium (Ga)-68 DOTATATE positron emission tomography (PET)/computed tomography (CT) in the prediction of the response to peptide receptor radionuclide therapy (PRRT) using lutetium (Lu)-177 DOTATATE. Materials and methods: Analysis was made of baseline Ga-68 DOTATATE PET/CT images of 29 patients (17 females and 12 males; mean age: 50.7 ± 14.6 years) with metastatic neuroendocrine tumors who received PRRT with Lu-177 DOTATATE. Maximum standardized uptake values (SUVmax) of reference lesions and their ratios to physiological uptake organs were calculated. The relationship between these values and the radiological response was analyzed. Results: Partial response was observed in 8 (28%) patients, stable disease in 18 (62%) patients, and progressive disease in 3 (10%) patients. Mean SUVmax of reference lesions was calculated as 23.8 ± 20.5 (min-max: 5.1-87.3). There was no significant correlation between radiological responses and SUVmax of reference lesions and their ratios to other organs. Conclusion: Baseline Ga-68 DOTATATE PET/CT helps to show somatostatin receptor expression status and disease stage in patients who are candidates for PRRT. However, SUVs do not have a role in the prediction of treatment response.
- Subjects
NEUROENDOCRINE tumors; RADIOISOTOPE therapy; POSITRON emission tomography; COMPUTED tomography; PEPTIDE drugs; GALLIUM; TUMOR treatment
- Publication
Turkish Journal of Medical Sciences, 2016, Vol 46, Issue 2, p409
- ISSN
1300-0144
- Publication type
Article
- DOI
10.3906/sag-1412-11