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- Title
Bacterial Coinfection and Antibiotic Resistance Profiles among Hospitalised COVID-19 Patients.
- Authors
Bazaid, Abdulrahman S.; Barnawi, Heba; Qanash, Husam; Alsaif, Ghaida; Aldarhami, Abdu; Gattan, Hattan; Alharbi, Bandar; Alrashidi, Abdulaziz; Al-Soud, Waleed Abu; Moussa, Safia; Alfouzan, Fayez
- Abstract
While it is reported that COVID-19 patients are more prone to secondary bacterial infections, which are strongly linked to the severity of complications of the disease, bacterial coinfections associated with COVID-19 are not widely studied. This work aimed to investigate the prevalence of bacterial coinfections and associated antibiotic resistance profiles among hospitalised COVID-19 patients. Age, gender, weight, bacterial identities, and antibiotic sensitivity profiles were collected retrospectively for 108 patients admitted to the intensive care unit (ICU) and non-ICU ward of a single center in Saudi Arabia. ICU patients (60%) showed a significantly higher percentage of bacterial coinfections in sputum (74%) and blood (38%) samples, compared to non-ICU. Acinetobacter baumannii (56%) and Klebsiella pneumoniae (56%) were the most prevalent bacterial species from ICU patients, presenting with full resistance to all tested antibiotics except colistin. By contrast, samples of non-ICU patients exhibited infections with Escherichia coli (31%) and Pseudomonas aeruginosa (15%) predominantly, with elevated resistance of E. coli to piperacillin/tazobactam and trimethoprim/sulfamethoxazole. This alarming correlation between multi-drug resistant bacterial coinfection and admission to the ICU requires more attention and precaution with prescribed antibiotics to limit the spread of resistant bacteria and improve therapeutic management.
- Subjects
SAUDI Arabia; COVID-19; ACINETOBACTER baumannii; BACTERIAL diseases; ESCHERICHIA coli diseases; ESCHERICHIA coli; INTENSIVE care patients
- Publication
Microorganisms, 2022, Vol 10, Issue 3, p495
- ISSN
2076-2607
- Publication type
Article
- DOI
10.3390/microorganisms10030495