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- Title
Combined peripheral and central ultrasound for the diagnosis of PAH‐SSc patients.
- Authors
Correale, Michele; Rotondo, Cinzia; Bevere, Ester Maria Lucia; Tricarico, Lucia; Rella, Valeria; Villani, Deborah; Granato, Mattia; Migliozzi, Celeste; Cantatore, Francesco Paolo; Brunetti, Natale Daniele; Corrado, Addolorata
- Abstract
Background: Systemic Sclerosis (SSc), an intricate autoimmune disease causing tissue fibrosis, introduces cardiovascular complexities, notably pulmonary hypertension (PH), affecting both survival and quality of life. This study centers on evaluating echocardiographic parameters and endothelial function using flow‐mediated dilatation (FMD) in SSc patients, aiming to differentiate those with and without pulmonary arterial hypertension (PAH). The emphasis lies in early detection, given the heightened vulnerability of the right ventricle (RV) in the presence of PH. Methods: Fifty‐nine SSc patients and 48 healthy subjects participated, undergoing clinical examinations, echocardiography, FMD assessments, blood analyses, and right heart catheterization (RHC) according to the ESC/ERS guidelines for diagnosis and treatment of PH. Results: SSc‐PAH patients displayed lower FMD, higher frequency of TAPSE < 18 mm, RA area > 18 cm2, act RVOT < 105 ms and TRV > 280 cm/s compared to those without PAH and healthy controls. Resting resistivity index (RI) was higher in SSc patients, with no significant difference between those with and without PAH. Lower FMD% serves as a predictive marker for adverse cardiovascular outcomes in both SSc and SSc‐PAH patients. Stratification by TRV levels and PAH presence reveals notable FMD% variations, emphasizing its potential utility. Conclusions: Early identification of endothelial dysfunction and impaired RV echocardiographic parameters, such as TAPSE and TRV, could aid in predicting right ventricular dysfunction and PAH in SSc patients.
- Subjects
ENDOTHELIUM physiology; PULMONARY hypertension diagnosis; ULTRASONIC imaging; DESCRIPTIVE statistics; SYSTEMIC scleroderma; PULMONARY arterial hypertension; ECHOCARDIOGRAPHY; CARDIAC catheterization
- Publication
Echocardiography, 2024, Vol 41, Issue 6, p1
- ISSN
0742-2822
- Publication type
Article
- DOI
10.1111/echo.15853