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- Title
PRO-INFLAMMATORY CYTOKINES INTERLEUKIN 6 AND TUMOR NECROSIS FACTOR-α IN DIABETIC AND NON-DIABETIC MYOCARDIAL INFARCTION PATIENTS TREATED BY ANGIOPLASTY.
- Authors
Jaleel, Farhan; Ghanghro, Allah Bux; Aqil, Saima; Qureshi, Muhammad Sameer; Ashraf, Tariq
- Abstract
Objective: To evaluate the levels of pro-inflammatory cytokines Interleukin-6, Tumor necrosis factor-α before and after angioplasty in patients of myocardial infarction with and without diabetes mellitus type II. Methodology: This cross sectional study included patients between the age of 40 and 60 years presented to National Institute of Cardiovascular diseases, Karachi. Patients were divided into 2 groups. First group comprised of myocardial infarction patients, second group included patients with myocardial infarction and diabetes mellitus type 2. Serum Interleukin-6, Tumor Necrosis Factor-α, serum triglycerides, cholesterol, LDL cholesterol HDL cholesterol, FBS, HbA1C and Insulin concentrations were determined. P value was determined by Students t test. Chi Square test was applied to gender and smoking. Results: We included 200 patients. The patients were divided into 2 groups and each group comprised of 100 subjects. First group comprised of Myocardial Infarction patients, second group Myocardial Infarction with Diabetes Mellitus type 2 patients Values of fasting blood glucose, glycosylated hemoglobin and insulin were significantly increased in myocardial infarction patients with diabetes as compared with myocardial infarction patients without diabetes (p<0.001). Serum HDL cholesterol concentrations were significantly decreased in myocardial infarction patients without diabetes (p<0.001). When values of cholesterol, triglycerides, LDL cholesterol, were compared, it was observed that they were non-significant. Interlekin-6 Tumor necrosis factor-α, were found to significantly higher in both groups prior to angioplasty as compared with post angioplasty levels (p<0.001). Conclusions: The study indicates that high levels of pro-inflammatory cytokines are found at the time of ischemia which play an important role in the cascade of MI. Levels were higher in patients regardless of diabetes mellitus status.
- Subjects
MYOCARDIAL infarction; TYPE 2 diabetes; HEMOGLOBINS; TUMORS; DIABETES; BLOOD cholesterol
- Publication
Pakistan Heart Journal, 2018, Vol 51, Issue 3, p211
- ISSN
0048-2706
- Publication type
Article