We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A lateral ridge augmentation study to evaluate a synthetic membrane for guided bone regeneration: an experiment in the canine mandible.
- Authors
Vierra, Matthew; Mau, Lian Ping; Huynh‐Ba, Guy; Schoolfield, John; Cochran, David L.
- Abstract
Objectives: To evaluate guided bone regeneration outcomes in defects protected with an in situ formed polyethylene glycol (PEG) hydrogel membrane as compared to a non-cross-linked collagen membrane (CM). Material and methods: Four mandibular alveolar ridge defects were created in eight hound dogs. Regenerative procedures were randomly allocated to one of four groups consisting of freeze-dried bone allograft, which is referred to in this study as freeze-dried bone xenograft (FDBX) + PEG, autogenous bone (AB) + PEG, AB + CM, and AB alone. After 8 weeks, titanium dental implants were placed into augmented sites. After 8 weeks of allowed time for osseointegration, the animals were sacrificed to harvest block specimens for bone-to-implant contact (BIC) and ridge width histomorphometric analysis. Results: Polyethylene glycol membranes had an exposure rate of 50% as compared to 12.5% for sites grafted with CM. Regenerative outcomes with respect to implant placement were least favorable for FDBX + PEG which had implants placed in 37.5% of augmented sites compared to 100% implant placement for all other groups. No statistically significant differences were noted between groups for ridge width measurements in implant and non-implant histologic sections (P > 0.05). Buccal BIC (%) values between treatment groups also failed to reach statistical significant difference (FDBX + PEG [60.2 ± 9.4]; AB + PEG [58.8 ± 8.5]; AB + CM [57.9 ± 12.8]; AB [61.0 ± 10.2]). Conclusion: When used in conjunction with FDBX, PEG had unpredictable bone formation and in most cases negatively impacted future implant placement.
- Subjects
BONE regeneration; BONE grafting; CUSPIDS; MANDIBLE; POLYETHYLENE glycol; HEALTH outcome assessment; PHYSIOLOGY
- Publication
Clinical Oral Implants Research, 2016, Vol 27, Issue 1, p73
- ISSN
0905-7161
- Publication type
Article
- DOI
10.1111/clr.12517