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- Title
Differential cytokine expressions affect the severity of peri-implant disease.
- Authors
Duarte, Poliana Mendes; De Mendonça, Adriana Cutrim; Máximo, Maria Beatriz Braz; Santos, Vanessa Renata; Bastos, Marta Ferreira; Nociti Júnior, Francisco Humberto
- Abstract
Objective: This study assessed gene expression by quantitative polymerase chain reaction of inflammatory- [interleukin (IL)-12, tumor necrosis factor-α (TNF-α), IL-4, and IL-10] and osteoclastogenesis-related factors [receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG)] in sites exhibiting different severities of peri-implant disease. Material and methods: Peri-implant soft tissue biopsies ( n=48) were harvested from healthy implant (HI), mucositis (MC), initial peri-implantitis (IP) and severe peri-implantitis (SP) sites. Results: IL-12 and TNF-α mRNA levels were higher in SP, followed by IP and MC ( P <0.05). IL-4 was higher in HI, followed by MC, SP and IP ( P <0.05). IL-10 was the lowest in HI, while no differences were detected among the diseased groups ( P>0.05). OPG mRNA levels were higher in HI, followed by IP, SP and MC, whereas RANKL was increased as the peri-implantitis severity increased ( P<0.05). The highest OPG/RANKL ratio was observed in HI and the lowest in SP ( P<0.01). Conclusion: These findings suggest that expressions of inflammatory- and osteoclastogenesis-related factors may play an important role in the onset and severity of the peri-implant diseases.
- Subjects
POLYMERASE chain reaction; TUMOR necrosis factors; DNA polymerases; GENE expression; INTERLEUKIN-12; SOFT tissue tumors; MESSENGER RNA; CYTOKINES
- Publication
Clinical Oral Implants Research, 2009, Vol 20, Issue 5, p514
- ISSN
0905-7161
- Publication type
Article
- DOI
10.1111/j.1600-0501.2008.01680.x