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- Title
Interleukin-32 Gamma Stimulates Bone Formation by Increasing miR-29a in Osteoblastic Cells and Prevents the Development of Osteoporosis.
- Authors
Lee, Eun-Jin; Kim, Sang-Min; Choi, Bongkun; Kim, Eun-Young; Chung, Yeon-Ho; Lee, Eun-Ju; Yoo, Bin; Lee, Chang-Keun; Hong, Seokchan; Kim, Beom-Jun; Koh, Jung-Min; Kim, Soo-Hyun; Kim, Yong-Gil; Chang, Eun-Ju
- Abstract
Interleukin-32 gamma (IL-32γ) is a recently discovered cytokine that is elevated in inflamed tissues and contributes to pathogenic features of bone in human inflammatory rheumatic diseases. Nevertheless, the role of IL-32γ and its direct involvement in bone metabolism is unclear. We investigated the molecular mechanism of IL-32γ in bone remodeling and the hypothetical correlation between IL-32γ and disease activity in osteoporosis patients. Transgenic (TG) mice overexpressing human IL-32γ showed reduced bone loss with advancing age, increased bone formation, and high osteogenic capacity of osteoblast compared to wild-type (WT) mice through the upregulation of miR-29a, which caused a reduction of Dickkopf-1 (DKK1) expression. IL-32γ TG mice were protected against ovariectomy (OVX)induced osteoporosis compared with WT mice. Decreased plasma IL-32γ levels were associated with bone mineral density (BMD) in human patients linked to increased DKK1 levels. These results indicate that IL-32γ plays a protective role for bone loss, providing clinical evidence of a negative correlation between IL-32γ and DKK1 as bone metabolic markers.
- Publication
Scientific Reports, 2017, p40240
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep40240