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- Title
Inclusion Complexes of β and HPβ-Cyclodextrin with α, β Amyrin and In Vitro Anti-Inflammatory Activity.
- Authors
da Silva Júnior, Walter Ferreira; Bezerra de Menezes, Danielle Lima; de Oliveira, Luana Carvalho; Koester, Letícia Scherer; Oliveira de Almeida, Patrícia Danielle; Lima, Emerson Silva; de Azevedo, Eduardo Pereira; da Veiga Júnior, Valdir Florêncio; Neves de Lima, Ádley Antonini
- Abstract
α, β amyrin (ABAM) is a natural mixture of pentacyclic triterpenes that has a wide range of biological activities. ABAM is isolated from the species of the Burseraceae family, in which the species Protium is commonly found in the Amazon region of Brazil. The aim of this work was to develop inclusion complexes (ICs) of ABAM and β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD) by physical mixing (PM) and kneading (KN) methods. Interactions between ABAM and the CD's as well as the formation of ICs were confirmed by physicochemical characterization in the solid state by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetry (TG) and differential scanning calorimetry (DSC). Physicochemical characterization indicated the formation of ICs with both βCD and HPβCD. Such ICs were able to induce changes in the physicochemical properties of ABAM. In addition, the formation of ICs with cyclodextrins showed to be an effective and promising alternative to enhance the anti-inflammatory activity and safety of ABAM.
- Subjects
BRAZIL; INCLUSION compounds; AMYRIN; DIFFERENTIAL scanning calorimetry; SCANNING electron microscopy; FOURIER transforms
- Publication
Biomolecules (2218-273X), 2019, Vol 9, Issue 6, p241
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom9060241