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- Title
Probiotics-Containing Yogurts Suppress Helicobacter pylori Load and Modify Immune Response and Intestinal Microbiota in the Helicobacter pylori-Infected Children.
- Authors
Yang, Yao-Jong; Sheu, Bor-Shyang
- Abstract
Background: The benefits of probiotics to the pediatric Helicobacter pylori infection remain uncertain. We tested whether the H. pylori-infected children have an altered gut microflora, and whether probiotics-containing yogurt can restore such change and improve their H. pylori-related immune cascades. Methods: We prospectively included 38 children with H. pylori infection confirmed by a positive 13C-urea breath test (UBT) and 38 age- and sex-matched noninfected controls. All of them have provided the serum and stool samples before and after 4-week ingestion of probiotics-containing yogurt. The serum samples were tested for the TNF-α, IL-10, IL-6, immunoglobulin (Ig) A, G, E, pepsinogens I and II levels. The stool samples were tested for the colony counts of Bifidobacterium spp. and Escherichia coli. The follow-up UBT indirectly assessed the H. pylori loads after yogurt usage. Results: The H. pylori-infected children had lower fecal Bifidobacterium spp. count ( p = .009), Bifidobacterium spp./ E. coli ratio ( p = .04), serum IgA titer ( p = .04), and pepsinogens I/II ratio ( p < .001) than in controls. In the H. pylori-infected children, 4-week yogurt ingestion reduced the IL-6 level ( p < .01) and H. pylori loads ( p = .046), but elevated the serum IgA and pepsinogen II levels ( p < .001). Moreover, yogurt ingestion can improve the childhood fecal Bifidobacterium spp./ E. coli ratio ( p = .03). Conclusions: The H. pylori-infected children have a lower Bifidobacterium microflora in gut. The probiotics-containing yogurt can offer benefits to restore Bifidobacterium spp./ E. coli ratio in children and suppress the H. pylori load with increment of serum IgA but with reduction in IL-6 in H. pylori-infected children.
- Subjects
PROBIOTICS; YOGURT; HELICOBACTER pylori infections; IMMUNE response; JUVENILE diseases; SERUM; PEPSINOGEN; ESCHERICHIA coli
- Publication
Helicobacter, 2012, Vol 17, Issue 4, p297
- ISSN
1083-4389
- Publication type
Article
- DOI
10.1111/j.1523-5378.2012.00941.x