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- Title
Xylans extracted from branches and leaves of Protium puncticulatum: antioxidant, cytotoxic, immunomodulatory, anticoagulant, antitumor, prebiotic activities and their structural characterization.
- Authors
da Cruz Filho, Iranildo José; de Souza, Thammyris Pires; dos Anjos Santos, Carolina Ávila; de Morais Araújo, Maria Augusta; de Oliveira Moraes Miranda, Josué Filipe; de Oliveira Queirós, Maria Emanuelle; Filho, Denilson José Nogueira Correia; da Conceição Alves de Lima, Alice; Marques, Diego Santa Clara; do Carmo Alves de Lima, Maria
- Abstract
This work aimed to isolate and characterize xylans from branches and leaves of Protium puncticulatum, in addition to evaluating its in vitro biological and prebiotic potential. The results showed that the chemical structure of the obtained polysaccharides is similar being classified as homoxylans. The xylans presented an amorphous structure, in addition to being thermally stable and presenting a molecular weight close to 36 g/mol. With regard to biological activities, it was observed that xylans were able to promote low antioxidant activity (< 50%) in the different assays evaluated. The xylans also showed no toxicity against normal cells, in addition to being able to stimulate cells of the immune system and showing promise as anticoagulant agents. In addition to presenting promising antitumor activity in vitro. In assays of emulsifying activity, xylans were able to emulsify lipids in percentages below 50%. Regarding in vitro prebiotic activity, xylans were able to stimulate and promote the growth of different probiotics. Therefore, this study, in addition to being a pioneer, contributes to the application of these polysaccharides in the biomedical and food areas.
- Subjects
XYLANS; MOLECULAR weights; ANTICOAGULANTS; POLYSACCHARIDES; CHEMICAL structure; ANTINEOPLASTIC agents
- Publication
3 Biotech, 2023, Vol 13, Issue 3, p1
- ISSN
2190-572X
- Publication type
Article
- DOI
10.1007/s13205-023-03506-1