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- Title
The impact of pathogen‐reduced platelets in acute leukaemia treatment on the total blood product requirement: a subgroup analysis of an EFFIPAP randomised trial.
- Authors
Garban, Frédéric; Vilotitch, Antoine; Tiberghien, Pierre; Bosson, Jean Luc
- Abstract
Objective: To evaluate the impact of pathogen‐reduced (PR) platelet transfusions on blood products requirement for clinical practice. Background: PR platelets are increasing in use as standard blood products. However, few randomised trials have evaluated their impact on bleeding control or prevention. Furthermore, PR platelets recirculate less than untreated platelets. Methods: A subgroup study of the randomised clinical trial EFFIPAP compared three arms of platelet preparations (PR: P‐PRP/PAS, additive solution: P‐PAS and plasma P‐P arms respectively). The subgroup of acute leukaemia patients, in their chemotherapy induction phase, included 392 patients (133 P‐PRP/PAS arm, 132 P‐PAS arm and 130 P‐P arm). Blood requirements were analysed across over periods of 7 days. Results: The number of platelet transfusions per week was significantly higher in the P‐PRP/PAS group 2.3 [1.6–3.3] compared to the control groups 1.9 [1.3–2.8] and 2.0 [1.3–3.0] for P‐P and P‐PAS groups respectively (p < 0.0001). However, the total number of platelets transfused per week was not different. The number of red blood cell concentrates (RBC) transfusion per week did not differ either. Conclusion: In a homogeneous group of patients, platelet pathogen reduction resulted in an increased number of platelet units transfused per week while having no impact on the total number of platelets transfused or the number of RBC transfusion; resulting to an average requirement of 2 RBC and 2–3 platelets transfusions per week of marrow aplasia.
- Subjects
BLOOD products; ACUTE leukemia; REQUIREMENTS engineering; BLOOD platelets; BLOOD platelet transfusion
- Publication
Transfusion Medicine, 2022, Vol 32, Issue 2, p175
- ISSN
0958-7578
- Publication type
Article
- DOI
10.1111/tme.12848