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- Title
HHV-8 Linked to Kaposi's Sarcoma and Castleman's Disease in HIV-1-infected patient: Case Report and Review of the Literature.
- Authors
Zaghdoudi, Aida; Harrabi, Hajer; Benaissa, Hanene Tiouiri
- Abstract
Kaposi's sarcoma (KS) and multicentric Castleman's disease (MCD) are both linked to human herpesvirus-8 (HHV-8) infection which most commonly affects people living with human immunodeficiency virus (HIV). Herein, we describe the case of a 57-year-old patient who has been admitted for fever, night sweats, weight loss, and diffuse lymphadenopathy with abdominal pain. HIV status was confirmed by a positive Western blot test. His initial CD4 cell count was equal to 270 cells/µL. A histological study of a peripheral lymph node concluded that KS is associated with MCD. These two conditions found in the same patient highlight the malignant potential of HHV-8, particularly in the case of HIV-induced immunodeficiency.
- Subjects
CASTLEMAN'S disease; KAPOSI'S sarcoma; LITERATURE reviews; KAPOSI'S sarcoma-associated herpesvirus; HIV; CD4 lymphocyte count
- Publication
International Journal of Hematology-Oncology & Stem Cell Research, 2024, Vol 18, Issue 2, p202
- ISSN
2008-3009
- Publication type
Case Study