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- Title
FLOATING MICROSPHERE: AN APPROACH TO ORAL CONTROLLED DRUG DELIVERY VIA GASTRIC RETENTION.
- Authors
Jaiswal Vicky, D.; Gujarathi Nayan, A.; Rane Bhushan, R.; Bakliwal Sunil, R.; Pawar, S. P.
- Abstract
Although marvelous advancement in drug delivery, oral route remains the preferred route for the administration due to higher levels of patient compliance. But conventional oral dosage forms not suggest control over drug delivery, leading to fluctuations in plasma drug level. A controlled drug delivery system provides not only prolonged residence time in the stomach but also great practical importance for drugs with an absorption window in the upper small intestine. Gastric emptying is a complex process, which is highly variable and makes in vivo performance of the drug-delivery systems doubtful. In order to avoid this variability, efforts have been made to increase the retention time of the drug-delivery systems for more than 12 h. The floating or hydrodynamically controlled drug-delivery systems are useful in such applications. The various buoyant preparations include hollow microspheres, granules, powders, tablets, capsules, pills and laminated films. For the targeting of drugs to stomach specially floating microsphere are widely utilized. These floating microspheres have the advantage that they remain buoyant and distributed uniformly over the gastric fluid to avoid the gastric emptying and release the drug for prolonged period of time. The present review addresses briefly the physiology of the gastric emptying process with respect to floating microspheres as drug-delivery systems.
- Subjects
DRUG delivery systems; DOSAGE forms of drugs; PATIENT compliance; HEALTH behavior; MICROSPHERES
- Publication
Pharma Science Monitor, 2012, Vol 3, Issue 4, p3099
- ISSN
0976-9242
- Publication type
Article