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- Title
A single center retrospective study of molecular classification in endometrial cancer patients.
- Authors
Min Sun Kyoung; Seung Ho Kim; Hye Yon Cho
- Abstract
Objective: The molecular classification of endometrial cancer (EC) has potential implications for adjuvant treatment strategies, and it can help to identify the specific treatment options based on individual tumor's molecular characteristics. We investigated the molecular classification of EC patients and described molecular and clinicopathological characteristics with International Federation of Gynecology and Obstetrics (FIGO) staging of EC 2023. Methods: A total of 32 EC patients who received fertility sparing treatment and staging surgery were retrospectively collected. Of the 11 patients allowed next-generation sequencing to identify molecular classification and immunohistochemistry in Hallym University Dongtan Sacred Heart Hospital from January 2022 to November 2023. We classified into four distinct molecular subgroups: polymerase-e exonuclease mutant (POLEm), mismatch repair deficient (MMRd), no specific molecular profile (NSMP), p53 abnormal (p53 abn). Results: A total of 11 patients were included and 72.7% of patients had FIGO stage I and 27.3% of patients had FIGO stage II/III. According to molecular classification, 2 patients (18.2%) were classified into POLEm group, 2 patients (18.2%) into MMRd group, 5 patients (45.4%) into NSMP group, and 2 patients (18.2%) into p53 abn group. The mean follow-up time was 8.1 months and overall survival was calculated as 9.8±6.4 months. Conclusion: Molecular classification of EC improves risk assessment when integrated with clinicopathologic features and provides personalized adjuvant treatment recommendations. This work shows the real-world data on clinical feasibility of molecular profiling for EC and its impact on clinical outcomes in further research.
- Subjects
ENDOMETRIAL cancer; TUMOR classification; CANCER patients; NUCLEOTIDE sequencing; OVERALL survival; ENDOMETRIAL tumors
- Publication
Journal of Gynecologic Oncology, 2024, Vol 35, p63
- ISSN
2005-0380
- Publication type
Article
- DOI
10.3802/jgo.2024.35.S2.P88