We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Histologic Chorioamnionitis, Amniotic Fluid Interleukin 6, Krebs von den Lungen 6, and Transforming Growth Factor β1 for the Development of Neonatal Bronchopulmonary Dysplasia.
- Authors
Hisako Matsumura; Hiroyuki Ichiba; Satoshi Ohnishi; Mika Saito; Haruo Shintaku
- Abstract
Background : Chorioamnionitis (CAM) is an important risk factor for the development of bronchopulmonary dysplasia (BPD) in preterm infants. Ob jecti ves: To evaluate the effects of CAM on the development of BPD using interleukin 6 (IL-6), Krebs von den Lungen 6 (KL-6), and transforming growth factor β1 (TGF-β1) in the amniotic fluid as markers for inflammation, lung injury, and fibrosis/remodeling, respectively. Meth ods: Amniotic fluid concentrations of IL-6, KL-6, and TGF-β1 were measured with enzyme-linked immunosorbent assay or electrochemiluminescence immunoassay. Results : Of the 36 preterm infants, 18 were exposed to histologically confirmed CAM. Of these, 12 were later diagnosed as having BPD. The IL-6, KL-6, and TGF-β1 levels in the amniotic fluid significantly increased with increasing histologic severity of CAM. Moreover, these markers were higher in the BPD group with histologic CAM than those without. Concl usi ons : Our study suggests that CAM is likely to induce inflammatory, injury, and remodeling processes in the fetal lung.
- Subjects
CHORIOAMNIONITIS; AMNIOTIC liquid; INTERLEUKIN-6; TRANSFORMING growth factor genetics; BRONCHOPULMONARY dysplasia
- Publication
Japanese Clinical Medicine, 2017, Issue 8, p1
- ISSN
1179-6707
- Publication type
Article
- DOI
10.1177/1179066017696076