We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
EFFECT OF pH AND SURFACTANTS ON DISSOLUTION PROFILE OF BCS CLASS II DRUGS.
- Authors
L., Pingale Prashant; S., Boraste Sahebrao
- Abstract
Physical and chemical properties of the Active Pharmaceutical Ingredients, including solubility and stability, as well as the formulation concept, play a vital role in the selection of the dissolution test apparatus, especially for poorly soluble compounds. The common problem associated with poorly water-soluble drugs, i.e., BCS Class II and IV in the selection of disintegration media with the potential to differentiate drug products. The disintegration medium is commonly used in a laboratory that cannot wholly dissolve poorly soluble drugs. The use of surfactant and pH correction is the most straight forward approach to improve the dissolution of poorly soluble drugs. Dissolution media with different pH and surfactants are an appropriate method for dissolving the drugs. Gastrointestinal fluids, e.g., bile salts, lecithin, cholesterol and its esters, contain various surfactants. Ibuprofen and Telmisartan both are class II drugs; hence the purpose of this study was to investigate the effect of multiple types of surfactants and pH on the dissolution rates of these poorly soluble drugs. Dissolution studies and the impact of the various surfactants on the dissolution profile of Ibuprofen were conducted using multiple dissolution media. In the cited research work, the dissolution profile rate and effect of surfactant on the dissolution of Telmisartan were studied.
- Subjects
PH effect; SURFACE active agents; DRUG solubility
- Publication
Journal of Advanced Scientific Research, 2020, Vol 11, p251
- ISSN
0976-9595
- Publication type
Article