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- Title
Aqueous extract of Ilex paraguariensis attenuates the progression of atherosclerosis in cholesterol-fed rabbits.
- Authors
Pamplona Mosimann, Ana Luiza; Wilhelm-Filho, Danilo; da Silva, Edson Luiz
- Abstract
Ilex paraguariensis aqueous extract (mate) is an antioxidant-rich beverage widely consumed in South American countries. Here we questioned whether mate could reduce the progression of atherosclerosis in 1% cholesterol-fed rabbits. New Zealand White male rabbits (n=32) were divided into four groups: control (C, n=5), control-mate (CM, n=5), hypercholesterolemic (HC, n=11) and hypercholesterolemic-mate (HCM, n=11). The daily water and mate extract consumption was approximately 400 ml. After 2 months of treatment, mate intake did not change the lipid profile or hepatic cholesterol content of control or hypercholesterolemic rabbits (p< 0.05). However, the atherosclerotic lesion area was considerably smaller in the hypercholesterolemic-mate group (HCM, 35.4% vs. HC, 60.1%; p<0.05). In addition, the aortic cholesterol content was around half that of the HC group (HCM, 36.8 vs. HC, 73.9 μg/mg of protein, p<0.05). In spite of this, the thiobarbituric acid-reactive substances (TBARS) in the atherosclerotic aorta, liver and serum, and the activity of the antioxidant enzymes in liver and aorta did not differ among groups (p>0.05). The results showed that Ilex paraguariensis extract can inhibit the progression of atherosclerosis in cholesterol-fed rabbits, although it did not decrease the serum cholesterol or aortic TBARS and antioxidant enzymes.
- Subjects
EXTRACTS; ANTIOXIDANTS; ATHEROSCLEROSIS; HYPERCHOLESTEREMIA; LABORATORY rabbits; BLOOD cholesterol; ENZYMES
- Publication
Biofactors, 2006, Vol 26, Issue 1, p59
- ISSN
0951-6433
- Publication type
Article
- DOI
10.1002/biof.5520260106