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- Title
Plasma Dynorphin A Concentration Reflects the Degree of Pruritus in Chronic Liver Disease: A Preliminary Report.
- Authors
SAGITA MONIAGA, Catharina; Shiho IWAMOTO; Tsuneo KITAMURA; Maki FUJISHIRO; Nobuaki TAKAHASHI; Katsunari KINA; Hideoki OGAWA; Mitsutoshi TOMINAGA; Kenji TAKAMORI
- Abstract
The article present a study which discusses that dynorphin A level and β-endorphin/dynorphin A ratio were consecutively attenuated and increased in plasma of chronic liver disease (CLD) patients with pruritus compared to those without. It mentions that plasma levels of endogenous opioids, especially dynorphin A, may objectively reflect the pruritus intensity in CLD patients; and also mentions under pathologic conditions, the liver accumulates and excretes endogenous opioids.
- Subjects
DYNORPHINS; ITCHING; REPORTING of diseases; LIVER diseases; CHRONIC diseases; GAMMA-glutamyltransferase; NALTREXONE
- Publication
Acta Dermato-Venereologica, 2019, Vol 99, Issue 4, p442
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-3139