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- Title
Extracellular vesicles—Potential link between periodontal disease and diabetic complications.
- Authors
Huang, Shengyuan; Lin, Jiang; Han, Xiaozhe
- Abstract
It has long been suggested that a bidirectional impact exists between periodontitis and diabetes. Periodontitis may affect diabetes glycemic control, insulin resistance, and diabetic complications. Diabetes can worsen periodontitis by delaying wound healing and increasing the chance of infection. Extracellular vesicles (EVs) are heterogeneous particles of membrane‐enclosed spherical structure secreted by eukaryotes and prokaryotes and play a key role in a variety of diseases. This review will introduce the biogenesis, release, and biological function of EVs from a microbial and host cell perspective, discuss the functional properties of EVs in the development of periodontitis and diabetes, and explore their role in the pathogenesis and clinical application of these two diseases. Their clinical implication and diagnostic value are also discussed.
- Subjects
EXTRACELLULAR vesicles; DISEASE complications; PERIODONTAL disease; GLYCEMIC control; INSULIN resistance; PORPHYROMONAS gingivalis
- Publication
Molecular Oral Microbiology, 2024, Vol 39, Issue 4, p225
- ISSN
2041-1006
- Publication type
Article
- DOI
10.1111/omi.12449