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- Title
Biochemical evaluation of patients with breast cancer.
- Authors
Nandhini, Thasleema; Priya, Jothi; Devi, R. Gayatri
- Abstract
Introduction: Breast cancer is the most common cancer worldwide. The incidence and mortality rate is increasing in developing countries as compare to developed countries. The aim of this study was to evaluate the effect of different courses of chemotherapy treatment on serum biochemical profile of breast cancer patients. In the present study, 200 breast cancer patients were selected to study variations in serum biochemical level of breast cancer patients. Materials and Methods: The mean values of blood urea nitrogen, creatinine, uric acid, aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]), alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase [SGPT]), and alkaline phosphatase (AP) were found to be 32.58 ± 19.7 mg/dl, 1.05 ± 0.59 mg/dl, 8.6 ± 1.3 mg/dl, 27.3 ± 4.02 U/L, 27.9 ± 10.24 U/L, and 111 ± 2 4.04 U/L before the start of chemotherapy courses. The mean values of total and direct bilirubin, total serum protein, albumin, and fasting and postprandial glucose level were 0.30 ± 1.3 mg/dl, 0.13 ± 0.11 mg/dl, 8.11 ± 0.5 g/dl, 3.5 ± 0.07 g/dl, 96 ± 25 mg/dl, and 110 ± 25mg/dl before the start of chemotherapy treatment. Results and Discussion: The level of serum blood urea nitrogen, uric acid, AP, bilirubin, and postprandial glucose level was found to be more than normal reference range; while the level of creatinine, (AST or SGOT), (ALT or SGPT), total serum protein, albumin, and fasting blood glucose level was reported to be within normal reference range during the different courses of chemotherapy. Conclusion: The present results suggest serum biochemical parameters as an important diagnostic tool in the disease monitoring and metastasis.
- Subjects
ASPARTATE aminotransferase; ALKALINE phosphatase; BREAST cancer; BLOOD proteins; BLOOD urea nitrogen; ALANINE aminotransferase; SERUM
- Publication
Drug Invention Today, 2019, Vol 11, Issue 8, p1883
- ISSN
0975-7619
- Publication type
Article