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- Title
APOBEC3G Polymorphisms and Implications for a Population with Chronic Hepatitis B Virus in Burkina Faso.
- Authors
Compaore, Tegwinde Rebeca; Ouattara, Abdoul Karim; Sawadogo, Isidore; Traore, Lassina; Sagna, Tani; Djigma, Florencia Wendkuuni; Ouedraogo, Henri Gautier; Simpore, Jacques
- Abstract
Host factors such as APOBEC3G were associated with hypermutation, which might interfere with HBV replication. The need to assess the impact of APOBEC3G polymorphisms on a hepatitis B-infected population is highlighted by a previous study. Thus, our study aimed to characterize two APOBEC3G single nucleotide polymorphisms and evaluate their association among chronic carriers of hepatitis B in Burkina Faso. Three hundred forty-five (345) individuals were recruited, including 106 HBsAg positive and 239 HBsAg negative. APOBEC3G polymorphisms rs6001417 and rs8177832 DNA genotyping were characterized by TaqMan allelic discrimination. The minor allele G of rs600417 frequency was higher among participants with chronic hepatitis B. Furthermore, rs600417 was associated with the dominant model p < 0.05 . Multivariate analysis for chronic hepatitis B risk factors shows that the risk of chronic hepatitis B for genotype CG and GG of rs6001417 seem to be significantly reduced and are, respectively, OR = 0.25 (95% CI 0.09–0.72, p ≤ 0.01) and OR = 0.08 (95% CI 0.02–0.31, p ≤ 0.001). In the analysis, the GG genotype of rs8177832 seems to increase the risk of chronic hepatitis B by more than six (6) times, and it was statistically significant OR = 6.41(95% CI 1.74–23.55, p ≤ 0.01). This study shows that APOBEC3G may be a susceptibility gene for chronic hepatitis B virus carriage in our context. The locus could contribute to the mediation of host native resistance to HBV infection.
- Subjects
BURKINA Faso; CHRONIC hepatitis B; HEPATITIS B virus; SINGLE nucleotide polymorphisms; DISEASE risk factors; HEPATITIS B; DISEASE resistance of plants
- Publication
International Journal of Microbiology, 2023, p1
- ISSN
1687-918X
- Publication type
Article
- DOI
10.1155/2023/8279500