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- Title
Extracorporeal Membrane Oxygenation–Dependent Fulminant Melioidosis From Caspase 4 Mutation Reversed by Interferon Gamma Therapy.
- Authors
Amali, Aseervatham Anusha; Ravikumar, Sharada; Chew, Wei Leong; Tan, Zhaohong; Sam, Qi Hui; Chen, Kaiwen W; Boucher, Dave; MacLaren, Graeme; Chai, Louis Yi Ann
- Abstract
We describe bedside-to-bench immunological and genetic elucidation of defective pyroptosis attributable to novel caspase 4 defect mediating pathogen-triggered inflammatory programmed cell death, in the setting of severe pneumonia and abscess-forming melioidosis in an overtly healthy host failing to clear Burkholderia pseudomallei infection, and how targeted adjunctive biological therapy led to a successful outcome.
- Subjects
GLYCOSYLATED hemoglobin; PNEUMONIA; BURKHOLDERIA infections; MELIOIDOSIS; GENETIC mutation; GENETICS; BURKHOLDERIA; INFLAMMATION; EXTRACORPOREAL membrane oxygenation; APOPTOSIS; INTERFERONS; BIOTHERAPY; TREATMENT effectiveness; CASPASES; IMMUNOTHERAPY
- Publication
Clinical Infectious Diseases, 2024, Vol 78, Issue 1, p94
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciad517