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- Title
In vitro antifungal activity of 9 ,10-dihydrophenanthrene-2- carboxylic acid isolated from a marine bacterium: Pseudomonas putida.
- Authors
Uzair, Bushra; Bano, Asma; Khan Niazi, Muhammad Bilal; Khan, Farah; Shah, Ghulam Mujtaba; Habiba, Ume; Khan, Nimra Naeem; Khan, Barkat Ali
- Abstract
An antifungal compound 9, 10-dihydrophenanthrene - 2 - carboxylic acid was isolated from a marine derived bacterium Pseudomonas putida isolated from surface water samples of Karachi fish harbor coast line. The structure was explored using extensive ID- and 2D-NMR spectroscopic techniques. The compound was found to be active against fungal strains obtained from clinical samples whereas strong activity was noted against Candida albicans with a MIC value of 20μg/ml, as the purified compound showed promising anticandidal activity a multidisciplinary approach is needed to explore further this compound as potential pharmacological lead compound against Candida spp and will add in the global hunt for clinically functional antifungal agents.
- Subjects
PSEUDOMONAS putida; MARINE bacteria; LEAD compounds; WATER; CARBOXYLIC acids; WATER sampling
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2018, p2733
- ISSN
1011-601X
- Publication type
Article