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- Title
Bayesian Variable Selection Methods for Matched Case-Control Studies.
- Authors
Asafu-Adjei, Josephine; Mahlet, G.Tadesse; Coull, Brent; Balasubramanian, Raji; Lev, Michael; Schwamm, Lee; Betensky, Rebecca
- Abstract
Matched case-control designs are currently used in many biomedical applications. To ensure high efficiency and statistical power in identifying features that best discriminate cases from controls, it is important to account for the use of matched designs. However, in the setting of high dimensional data, few variable selection methods account for matching. Bayesian approaches to variable selection have several advantages, including the fact that such approaches visit a wider range of model subsets. In this paper, we propose a variable selection method to account for case-control matching in a Bayesian context and apply it using simulation studies, a matched brain imaging study conducted at Massachusetts General Hospital, and a matched cardiovascular biomarker study conducted by the High Risk Plaque Initiative.
- Subjects
STATISTICAL decision making; BIOMEDICAL materials; BAYES' estimation; PROBABILITY theory; SIMULATION methods in testing
- Publication
International Journal of Biostatistics, 2017, Vol 13, Issue 1, p-1
- ISSN
1557-4679
- Publication type
Article
- DOI
10.1515/ijb-2016-0043