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- Title
COMPARISON OF THE ANESTHETIC EFFECTS BETWEEN ACEPROMAZINEKETAMINE-XYLAZINE AND ACEPROMAZINE-KETAMINE-MEDETOMIDINE ON RABBIT LIVER AND KIDNEY FUNCTION.
- Authors
Rickyawan, Nofan
- Abstract
Rabbits are one of exotic animals that often come to the vet. Anesthesia in rabbits is necessary to manage stress and pain during medical procedures. Apart from causing unconscious effects, anesthesia also affects the function of organs including the liver and kidneys. This study aims to compare the anesthetic effects of combination acepromazine-ketamine-xylazine (AKX) and acepromazineketamine-medetomdine (AKM) on the kidney and liver function of rabbits. Nine male New Zealand White rabbits aged 6 months with an average body weight of 2 kg received 2 consecutive treatments at 2 week intervals. The first treatment (AKX), rabbits were given intramuscular injection of acepromazine 1 mg/kg - ketamine 35 mg/kg - xylazine 5 mg/kg. The second treatment (AKM), rabbits were given intramuscular injection of acepromazine 1 mg/kg - ketamine 35 mg/kg - medetomidine 0.1 mg/kg. Blood samples were taken in pre-anesthesia, peri-anesthesia and post-anesthesia for measurement of ALT, AST, BUN and creatinine levels. The result showed that both treatments affected liver and kidney function as indicated by an increase in levels of ALT, AST, BUN, creatinine which were still in the normal range. There was a significant difference between pre-anesthesia, peri-anesthesia and post-anesthesia in each treatment (P<0.05). There was no significant difference in the increase in enzyme levels between AKX and AKM (P>0.05). AKX and AKM are equally safe to use for anesthesia in rabbits based on their effect on liver and kidney function.
- Subjects
KIDNEY physiology; INTRAMUSCULAR injections; RABBITS; ANESTHETICS; EXOTIC animals; PAIN management; LIVER
- Publication
Veterinary Practitioner, 2020, Vol 21, p494
- ISSN
0972-4036
- Publication type
Article