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- Title
Advanced Endoscopic Imaging for Surveillance for Dysplasia and Colorectal Cancer in inflammatory Bowel Disease: Could the Pathologist be Further Helped?
- Authors
Sinagra, Emanuele; Tomasello, Giovanni; Raimondo, Dario; Sturm, Andreas; Giunta, Marco; Messina, Marco; Damiano, Giuseppe; Palumbo, Vincenzo D.; Spinelli, Gabriele; Rossi, Francesca; Facella, Tiziana; Marasà, Salvatore; Cottone, Mario; Monte, Attilio I. Lo
- Abstract
Patients with inflammatory bowel disease (IBD) have an increased risk of developing intestinal cancer. The magnitude of that increased risk as well as how best to mitigate it remain a topic of ongoing investigation in the field. It is important to quantify the risk of colorectal cancer in association with IBD. The reported risk varies widely between studies. This is partly due to the different methodologies used in the studies. Because of the limitations of surveillance strategies based on the detection of dysplasia, advanced endoscopic imaging and techniques involving the detection of alterations in mucosal antigens and genetic abnormalities are being investigated. Development of new biomarkers, predicting future occurrence of colonic neoplasia may lead to more biomarker-based surveillance. There are promising results that may lead to more efficient surveillance in IBD patients and more general acceptance of its use. A multidisciplinary approach, involving in particular endoscopists and pathologists, together with a centralized patient management, could help to optimize treatments and follow-up measures, both of which could help to reduce the IBD-associated cancer risk.
- Subjects
TUMOR prevention; RECTUM tumors; THERAPEUTIC use of biochemical markers; COLON tumor prevention; PUBLIC health surveillance; ENDOSCOPY; ANTIGENS; DATABASES; CROHN'S disease; HEALTH care teams; INFLAMMATORY bowel diseases; META-analysis; RISK assessment; ULCERATIVE colitis; SYSTEMATIC reviews; GENOMICS; DISEASE complications
- Publication
Saudi Journal of Gastroenterology, 2014, Vol 20, Issue 1, p26
- ISSN
1319-3767
- Publication type
Article
- DOI
10.4103/1319-3767.126314