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- Title
Structure Identification and Evaluation of Chemical Components from the Flos Sophorae Immaturus for Inhibitory Effects against HepG2.
- Authors
Zhaohui Xue; Weichen Song; Xin Gao; Wancong Yu; Xiaonan Hou; Xiaohong Kou
- Abstract
Flos Sophorae Immaturus, dried buds of Sophora japonica, exhibits multiple pharmacologic activities including anti-inflammatory, antiaging, and antiallergy effects as well as adjunct to standard of care cancer therapy. However, active components responsible for beneficial effects in cancer are not known. In this study, Flos Sophorae Immaturus was obtained by ethanol extraction, and eight components were purified, identified, and tested for HepG2 cell proliferation inhibition potency. The compounds identified to be the most effective inhibitors were campherol > isorhamnetin > quercetin. These data provide theoretical and scientific basis for the further development, utilization, and the promotion of added value of Flos Sophorae Immaturus.
- Subjects
MEDICINAL plants; ONE-way analysis of variance; CELL survival; CELL proliferation; DESCRIPTIVE statistics; PLANT extracts; MOLECULAR structure; CELL lines; DATA analysis software
- Publication
Current Topics in Nutraceutical Research, 2021, Vol 19, Issue 4, p452
- ISSN
1540-7535
- Publication type
Article
- DOI
10.37290/ctnr2641-452X.19:452-457