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- Title
Detección de polimorfismos en el gen GRIN1 del receptor ionotrópico de glutamato activado por NMDA en una población de Bogotá.
- Authors
OJEDA, DIEGO; LAREO, LEONARDO; AYALA, PAOLA; ZARANTE, IGNACIO
- Abstract
The ionotropic glutamate receptor activated by N-methyl- D-aspartate is composed by three different kinds of subunits NRI, NR2A to D and NR3A and B, which are codified by GRINI, GRIN2 and GRIN3 genes. Since the GRIN genomic variability is closely related to the genetic history, of the studied population, it was necessary to develop a detailed study of the frequency of the polymorphisms of the gene GRIN-I in Colombian population. The main goal of this research was to identify polymorphisms present in 5′-UTR region and exon 6 of gene GRINI, among 101 samples of umbilical cord taken on filter paper of healthy newborns at the University Hospital San lgnacio in Bogota. It was found that polymorphism AI970G with minor allele frequencies of 28.21%, doesn't differ significantly from the frequencies in Caucasian and native American populations. Polymorphism G1140A with minor allele frequencies of 1.49% did not show any significant statistic difference with the Taiwan population. Polymorphism A1160G just showed one allelic form, the A allele.
- Subjects
BOGOTA (Colombia); COLOMBIA; GENETIC polymorphisms; CELL receptors; GLUTAMIC acid; METHYL aspartate
- Publication
Universitas Médica, 2009, Vol 50, Issue 3, p335
- ISSN
0041-9095
- Publication type
Article