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- Title
Catheter Based Interventional Treatment of Acute Ischemic Stroke Beyond 3 Hours -- 3 Month Outcomes and Long Term Follow Up.
- Authors
Vijaya, P.; Suneeta, M.; Rao, N. Srinivasa; Anuradha, Anil; Sarma, P. V. Raghava
- Abstract
Introduction: Intra arterial Urokinase thrombolysis (IAT) is shown to be effective in several case studies and one RCT study (PROACT). Emergent angioplasty/ Stenting of intra and extra cranial occluded vessels is also shown to be feasible and effective as an adjuvant therapy in this setting. However limited data is available about the long term effect. We present our 3 month outcomes and also 2 years follow up of the initial 40 patients who received multimodal intra arterial reperfusion therapy in our center. Methods: 40 consecutive Acute Ischemic stroke patients were treated with IAT using Urokinase & PTBA / Stenting when required. The three months, 1 year and 2 yr outcomes were derived by either direct examination or by telephonic interview. The mRS score 0-2 was taken as good outcome. Results: Of the 40 pts, 4 (10%) people died in the hospital, 1 pt with symptomatic Hge., 2 had massive infarcts and one patient had aspiration. 2 patients who attained mRS-2 at discharge died of cardiac failure within 3 months. 25 Pts (62.5%) had excellent outcome at 3 months and maintained same at the end of 1yr. 9 (22.5%) patients were dependant at 3 months. Of this group 2 died in bedridden stage within 1year, 3 remained dependant, 4 people attained mRS-3 within 1 year. At the end of 2 years, 3 pts lost the follow up and the remaining 22 (55%) maintained the Good outcome. Conclusion: Our study showed significant and sustained effect of IAT in Acute Ischemic stroke.
- Subjects
CATHETERIZATION; CEREBROVASCULAR disease; ISCHEMIA; HEALTH outcome assessment; UROKINASE; THROMBOLYTIC therapy; REPERFUSION
- Publication
Annals of Indian Academy of Neurology, 2008, Vol 11, pS157
- ISSN
0972-2327
- Publication type
Article