We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Influence of subclass-specific anti-idiotypic antibodies on the kinetics of the immune response to BCG.
- Authors
Daus, H.; Hammer, H.-J.; Rajki, Klara; Mauch, H.
- Abstract
The role of anti-idiotypic subclass-specific antibodies was analysed in the regulation of the immune response to BCG in the guinea-pig. The idiotypes to BCG were separated into subclasses and anti-idiotypes were carried out by immunizing with the purified IgG1 and IgG2 anti-idiotypes. The in vivo T cell response was recorded by tuberculin skin testing, and the in vitro response by lymphocyte stimulation testing with tuberculin. A suppressive effect was detected in cases where the animals were preimmunized with anti-idiotypic IgG2 against antiBCG IgG1. In the B cell response, the anti-BCG IgG1 and IgG2 subclasses were also quantified by n solid-phase radioimmunoassay. There were 10 times more IgG2 antibodies than IgG1 against BCG in the guinea-pig, and this major idiotypic subclass was suppressed by the IgG2 anti-idiotype raised against anti-BCG IgG2. The minor component anti-BCG IgG1 was slightly stimulated by both IgG2 anti-idiotypes.
- Subjects
IMMUNE response; BCG vaccines; IMMUNOGLOBULIN G; B cells; TUBERCULIN; RADIOIMMUNOASSAY; GUINEA pigs as laboratory animals; T cells
- Publication
Immunology, 1984, Vol 52, Issue 4, p697
- ISSN
0019-2805
- Publication type
Article