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- Title
Effect of Long-term Administration of Fluoride on the Levels of EDTA-soluble Protein and y-Carboxyglutamic Acid in Rat Incisor Teeth.
- Authors
SMID, J. R.; deJERSEY, J.; KRUGER, B. J.
- Abstract
EDTA-soluble material, extracted from incisor teeth of rats given 50 ppm fluoride (NaF) in drinking water ad libitum from conception to age nine wk, contained significantly higher levels of protein (P<0.01) and γ-carboxyglutamic acid (P<0.01) than did similar material from control rats. Tooth fluoride levels indicated that the incisors were mildly fluorosed. Analysis of these data indicates that mild fluorosis of rat incisor teeth involves not only the characteristic disturbances of pigmentation and mineral structure but also some alteration of the matrix protein.
- Subjects
DENTAL research; TEETH; LABORATORY rats; INCISORS; FLUOROSIS; PHYSIOLOGICAL effects of fluorides
- Publication
Journal of Dental Research, 1984, Vol 63, Issue 8, p1061
- ISSN
0022-0345
- Publication type
Article
- DOI
10.1177/00220345840630081001