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- Title
Biocatalytic oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol by Nocardia corallina B-276.
- Authors
Ramirez, Mario A.; Perez, Herminia I.; Manjarrez, Norberto; Solis, Aida; Luna, Hector; Cassani, Julia
- Abstract
Chiral diarylmethanols are versatile building blocks for the preparation of biologically active substances, but they are difficult to obtain in enantiopure form. We used Nocardia corallina B-276 for the oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol, 1. Two experimental methods were used: 1) Suspension of cells in a phosphate buffer solution and 2) Cells in the culture media, in a 3-L bioreactor. After 36 hrs using the first method, the ketone/alcohol ratio was 56/44 and the unoxidized alcohol had an enantiomeric ratio of 93/7, predominating the R-alcohol.
- Subjects
NOCARDIA corallina; CELLS; BUFFER solutions; CELL suspensions; ALCOHOL; KETONES; ENZYMES; OXIDATION; CELL culture; NOCARDIA
- Publication
Electronic Journal of Biotechnology, 2008, Vol 11, Issue 4, p1
- ISSN
0717-3458
- Publication type
Article
- DOI
10.2225/vol11-issue4-fulltext-3