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- Title
Fusobacterium nucleatum bacteremia complicated with intracranial Porphyromonas gingivalis and HSV-1 infection: a case report and literature review.
- Authors
Wang, Sumei; Tian, Yaqiong; Wu, Yujing; Yu, Zhen; Zhang, Jinjuan; Zhang, Jiandong; Liu, Shuye
- Abstract
Background: Fusobacterium nucleatum (F. nucleatum) belongs to the genus Fusobacterium, which is a gram-negative obligate anaerobic bacterium. Bacteremia associated with F. nucleatum is a serious complication, which is not common in clinic, especially when it is combined with other intracranial pathogenic microorganism infection. We reported for the first time a case of F. nucleatum bacteremia combined with intracranial Porphyromonas gingivalis (P. gingivalis) and herpes simplex virus type 1(HSV-1) infection. Case presentation: A 60-year-old woman was admitted to our hospital with a headache for a week that worsened for 2 days. Combined with history, physical signs and examination, it was characterized as ischemic cerebrovascular disease (ICVD). F. nucleatum was detected in blood by matrix-assisted laser desorption/ionization time-offight mass spectrometry (MALDI-TOF-MS). Meanwhile, P. gingivalis and HSV-1 in cerebrospinal fluid (CSF) were identified by metagenome next generation sequencing (mNGS). After a quick diagnosis and a combination of antibiotics and antiviral treatment, the patient recovered and was discharged. Conclusion: To our knowledge, this is the first report of intracranial P. gingivalis and HSV-1 infection combined with F. nucleatum bacteremia.
- Subjects
PORPHYROMONAS gingivalis infections; LITERATURE reviews; HUMAN herpesvirus 1; NUCLEOTIDE sequencing; FUSOBACTERIUM
- Publication
BMC Infectious Diseases, 2024, Vol 24, Issue 1, p1
- ISSN
1471-2334
- Publication type
Case Study
- DOI
10.1186/s12879-024-09078-6