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- Title
Prospective association of serum androgens and sex hormone-binding globulin with subclinical cardiovascular disease in young adult women: the "Coronary Artery Risk Development in Young Adults" women's study.
- Authors
Calderon-Margalit, R; Schwartz, S M; Wellons, M F; Lewis, C E; Daviglus, M L; Schreiner, P J; Williams, O D; Sternfeld, B; Carr, J J; O'Leary, D H; Sidney, S; Friedlander, Y; Siscovick, D S
- Abstract
<bold>Context: </bold>The role of endogenous androgens and SHBG in the development of cardiovascular disease in young adult women is unclear.<bold>Objective: </bold>Our objective was to study the prospective association of serum androgens and SHBG with subclinical coronary and carotid disease among young to middle-aged women.<bold>Design and Setting: </bold>This was an ancillary study to the Coronary Artery Risk Development in Young Adults (CARDIA) study, a population-based multicenter cohort study with 20 yr of follow-up.<bold>Participants: </bold>Participants included 1629 women with measurements of serum testosterone and SHBG from yr 2, 10, or 16 and subclinical disease assessment at yr 20 (ages 37-52 yr).<bold>Main Outcome Measures: </bold>Coronary artery calcified plaques (CAC) and carotid artery intima-media thickness (IMT) were assessed at yr 20. The IMT measure incorporated the common carotid arteries, bifurcations, and internal carotid arteries.<bold>Results: </bold>SHBG (mean of yr 2, 10, and 16) was inversely associated with the presence of CAC (multivariable adjusted odds ratio for women with SHBG levels above the median = 0.59; 95% confidence interval = 0.40-0.87; P = 0.008). SHBG was also inversely associated with the highest quartile of carotid-IMT (odds ratio for women with SHBG levels in the highest quartile = 0.56; 95% confidence interval = 0.37-0.84; P for linear trend across quartiles = 0.005). No associations were observed for total or free testosterone with either CAC or IMT.<bold>Conclusion: </bold>SHBG levels were inversely associated with subclinical cardiovascular disease in young to middle-aged women. The extent to which low SHBG is a risk marker or has its own independent effects on atherosclerosis is yet to be determined.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2010, Vol 95, Issue 9, p4424
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2009-2643