We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis of New of 4-Thiazolidinone and Thiazole Derivatives Containing Coumarin Moiety with Antimicrobial Activity.
- Authors
Al-Harbi, Reem A. K.; El-Sharief, Marwa A. M. Sh.; Abbas, Samir Y.
- Abstract
Synthesizing hybrid molecules is one of the best manners to achieve novel promising agents. Consequently, series of new thiazoles having coumarin nucleus were synthesized from 3-acetylcoumarin thiosemicarbazones. Cyclization of thiosemicarbazone derivatives with ethyl 2-chloroacetate, 1-chloropropan-2-one and 2-bromo-1-phenylethanone afforded the corresponding 4-thiazolidinones, 4-methylthiazoles and 4-phenylthiazoles, respectively. The expected antimicrobial proprieties for the synthesized thiosemicarbazone and thiazole derivatives were investigated. The thiosemicarbazones and thiazolidin-4-ones showed moderate activities against Gram-positive and Gram-negative bacteria.
- Subjects
THIAZOLE derivatives; THIAZOLES; COUMARIN derivatives; ANTI-infective agents; THIOSEMICARBAZONES; MOIETIES (Chemistry)
- Publication
Acta Chimica Slovenica, 2023, Vol 70, Issue 4, p500
- ISSN
1318-0207
- Publication type
Article
- DOI
10.17344/acsi.2023.8281