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- Title
Impact of Cotadutide drug on patients with type 2 diabetes mellitus: a systematic review and meta-analysis.
- Authors
Ali, Mahmoud M.; Hafez, Ahmed; Abdelgalil, Mahmoud Shaban; Hasan, Mohammed Tarek; El-Ghannam, Mohammed Magdy; Ghogar, Osama M.; Elrashedy, Asmaa Ahmed; Abd-ElGawad, Mohamed
- Abstract
Background: The food and drug administration approved many drugs to treat diabetes mellitus, but those drugs do not have a noticeable effect on weight management. Recently, glucagon-like peptide 1 agonist known as Cotadutide serve as a potent drug in treating type 2 diabetes by reducing blood glucose levels and body weight indices. This study aimed to explore the safety and efficacy of Cotadutide as a treatment for type 2 diabetes individuals. Methods: A comprehensive literature search was done on different databases, including PubMed, Scopus, Web of Science, and Cochrane Library to capture all relevant articles using an established search strategy. The inclusion criteria were randomized controlled trials that assessed the safety and efficacy of Cotadutide versus placebo or any anti-diabetes drugs in patients with type 2 diabetes mellitus and a BMI between 22 kg/m2 and 40 kg/m2. We conducted the analysis using Revman software version 5.4. Results: We found 663 relevant articles. From which nine studies were included and subjected to qualitative analysis and eight for quantitative analysis. The pooled effect showed that Cotadutide was better than placebo in reducing body weight (kg) (Mean difference (MD) = 3.31, p < 0.00001), glycated hemoglobin (HbA1c) (MD = 0.68, p > 0.00001), glucose area under the plasma concentration curve (AUC [0-4 h]) (MD = 30.15, p < 0.00001), and fasting plasma glucose over time (mg/dl) (MD = 31.31, p < 0.00001). Conclusion: Cotadutide is safe and effective in reducing plasma glucose levels, HbA1c and body weight in individuals with type 2 diabetes. Trial registration: The study protocol was registered on PROSPERO (CRD: CRD42021257670).
- Subjects
DRUG efficacy; ONLINE information services; MEDICAL databases; GLYCOSYLATED hemoglobin; META-analysis; BODY weight; SYSTEMATIC reviews; CELL receptors; INVESTIGATIONAL drugs; BLOOD sugar; TYPE 2 diabetes; MEDLINE; DATA analysis software; PATIENT safety; PHARMACODYNAMICS; EVALUATION
- Publication
BMC Endocrine Disorders, 2022, Vol 22, Issue 1, p1
- ISSN
1472-6823
- Publication type
Article
- DOI
10.1186/s12902-022-01031-5