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- Title
Novel Naphthalimide Derivatives as Selective G-Quadruplex DNA Binders.
- Authors
Yildiz, Ufuk; Coban, Burak
- Abstract
A new derivate of 4-bromo-1,8-naphthalic anhydride and its quaternized analogue have been prepared and characterized. The interactions of both derivatives with human telomere quadruplex-DNA and ds-DNA have been comparatively studied by UV-visible (UV-Vis), fluorescent intercalator displacement assays, competition dialysis, circular dichroism (CD), agarose gel electrophoresis, and polyacrylamide gel electrophoresis. The results show that both derivatives can stabilize G-quadruplexes DNA, and they show different binding affinities for G-quadruplexes-DNA and ds-DNA. All spectroscopic studies have shown that the derivatives have a modest selectivity for G-quadruplex versus ds-DNA.
- Subjects
NAPHTHALIMIDES; QUADRUPLEX nucleic acids; DNA-binding proteins; GEL electrophoresis; CIRCULAR dichroism
- Publication
Applied Biochemistry & Biotechnology, 2018, Vol 186, Issue 3, p547
- ISSN
0273-2289
- Publication type
Article
- DOI
10.1007/s12010-018-2749-8