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- Title
Serological Humoral Immunity Following Natural Infection of Children with High Burden Gastrointestinal Viruses.
- Authors
Zweigart, Mark R.; Becker-Dreps, Sylvia; Bucardo, Filemón; González, Fredman; Baric, Ralph S.; Lindesmith, Lisa C.
- Abstract
Acute gastroenteritis (AGE) is a major cause of morbidity and mortality worldwide, resulting in an estimated 440,571 deaths of children under age 5 annually. Rotavirus, norovirus, and sapovirus are leading causes of childhood AGE. A successful rotavirus vaccine has reduced rotavirus hospitalizations by more than 50%. Using rotavirus as a guide, elucidating the determinants, breath, and duration of serological antibody immunity to AGE viruses, as well as host genetic factors that define susceptibility is essential for informing development of future vaccines and improving current vaccine candidates. Here, we summarize the current knowledge of disease burden and serological antibody immunity following natural infection to inform further vaccine development for these three high-burden viruses.
- Subjects
NATURAL immunity; HUMORAL immunity; ROTAVIRUSES; ROTAVIRUS vaccines; VACCINE development; VIRUSES; ROTAVIRUS diseases; NOROVIRUS diseases
- Publication
Viruses (1999-4915), 2021, Vol 13, Issue 10, p2033
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v13102033