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- Title
Ruthenium-Catalyzed meta-Selective CH Bromination.
- Authors
Teskey, Christopher J.; Lui, Andrew Y. W.; Greaney, Michael F.
- Abstract
The first example of a transition-metal-catalyzed, meta-selective CH bromination procedure is reported. In the presence of catalytic [{Ru(p-cymene)Cl2}2], tetrabutylammonium tribromide can be used to functionalize the meta CH bond of 2-phenylpyridine derivatives, thus affording difficult to access products which are highly predisposed to further derivatization. We demonstrate this utility with one-pot bromination/arylation and bromination/alkenylation procedures to deliver meta-arylated and meta-alkenylated products, respectively, in a single step.
- Subjects
RUTHENIUM catalysts; TRANSITION metal catalysts; CARBON-hydrogen bonds; BROMINATION; ARYLATION; ALKENYLATION; 2-Phenylpyridine
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 40, p11843
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201504390