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- Title
Herpesviruses Placating the Unwilling Host: Manipulation of the MHC Class II Antigen Presentation Pathway.
- Authors
Jianmin Zuo; Rowe, Martin
- Abstract
Lifelong persistent infection by herpesviruses depends on the balance between host immune responses and viral immune evasion. CD4 T cells responding to antigens presented on major histocompatibility complex class II (MHC-II) molecules are known to play an important role in controlling herpesvirus infections. Here we review, with emphasis on human herpesvirus infections, the strategies evolved to evade CD4 T cell immunity. These viruses target multiple points on the MHC class II antigen presentation pathway. The mechanisms include: suppression of CIITA to inhibit the synthesis of MHC class II molecules, diversion or degradation of HLA-DR molecules during membrane transport, and direct targeting of the invariant chain chaperone of HLA-DR.
- Subjects
HERPESVIRUSES; IMMUNE response; HISTOCOMPATIBILITY; T cells; MOLECULAR chaperones; ANTIGENS
- Publication
Viruses (1999-4915), 2012, Vol 4, Issue 8, p1335
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v4081335