We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A Platinum(II)-based Photosensitive Tripod as an Effective Photodynamic Anticancer Agent through DNA Damage.
- Authors
Zhong, Yi ‐ Fang; Zhang, Hang; Liu, Wen ‐ Ting; Zheng, Xiao ‐ Hui; Zhou, Yi ‐ Wei; Cao, Qian; Shen, Yong; Zhao, Yong; Qin, Peter Z.; Ji, Liang ‐ Nian; Mao, Zong ‐ Wan
- Abstract
Herein, two photosensitive platinum(II)-based tripods were designed and synthesized. Notably, complex 1 ({[Pt(dien)]3 L}(NO3)6, L=tri(4-pyridylphenyl)amine and dien=diethylenetriamine), which mainly accumulated in the cell nucleus, exhibited very low cytotoxicity in the absence of light irradiation, but displayed a remarkable increase in cytotoxicity upon visible light irradiation. Mechanistic investigations revealed that the tripod interacted with DNA in the nucleus, induced ROS generation upon light irradiation, and consequently elicited rapid DNA damage response; thereby triggering cancer cell apoptosis.
- Subjects
PLATINUM compounds; PHOTOSENSITIVITY; PHOTODYNAMIC therapy; ANTINEOPLASTIC agents; DNA damage
- Publication
Chemistry - A European Journal, 2017, Vol 23, Issue 65, p16442
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201703598