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- Title
Frontispiece: Visible-Light-Mediated Two-Fold Unsymmetrical C(sp<sup>3</sup>)−H Functionalization and Double C−F Substitution.
- Authors
Li, Linyong; Xiao, Tiebo; Chen, Haoguo; Zhou, Lei
- Abstract
Photoredox Catalysis A visible light ‐ mediated [3+3] annulation of tertiary amines with α ‐ trifluoromethyl alkenes was developed. The reaction offers a direct route to fluorinated tetrahydropyridines and azabicyclo[3.m.1] frameworks under very mild conditions. This protocol presents a rare example of dual sp3 C−H functionalization of tertiary amines with the formation of two different C−C bonds (one sp3−sp3 bond, one sp2−sp3 bond). Moreover, two consecutive C−F substitutions in a trifluoromethyl group were achieved in one ‐ pot using visible light photoredox catalysis, which enables an unprecedented ring construction. More information can be found in the Communication by L. Zhou et al. on page 2249 ff.
- Subjects
OXIDATION-reduction reaction; CATALYSIS
- Publication
Chemistry - A European Journal, 2017, Vol 23, Issue 10, pn/a
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201605919