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- Title
Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells.
- Authors
Croissant, Jonas G.; Fatieiev, Yevhen; Julfakyan, Khachatur; Lu, Jie; Emwas, Abdul‐Hamid; Anjum, Dalaver H.; Omar, Haneen; Tamanoi, Fuyuhiko; Zink, Jeffrey I.; Khashab, Niveen M.
- Abstract
We describe biodegradable mesoporous hybrid nanoparticles (NPs) in the presence of proteins and their applications for drug delivery. We synthesized oxamide phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of a silica source which had remarkably high organic content and high surface areas. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt %), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.
- Subjects
BIODEGRADABLE materials; SILICONES; DRUG delivery systems; ENZYMES; NANOPARTICLES
- Publication
Chemistry - A European Journal, 2016, Vol 22, Issue 42, p14806
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201601714