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- Title
Severity of SARS-CoV-2 infection is linked to double-negative (CD27<sup>−</sup> IgD<sup>−</sup>) B cell subset numbers.
- Authors
Cervantes-Díaz, Rodrigo; Sosa-Hernández, Víctor Andrés; Torres-Ruíz, Jiram; Romero-Ramírez, Sandra; Cañez-Hernández, Mariana; Pérez-Fragoso, Alfredo; Páez-Franco, José C.; Meza-Sánchez, David E.; Pescador-Rojas, Miriam; Sosa-Hernández, Víctor Adrián; Gómez-Martín, Diana; Maravillas-Montero, José L.
- Abstract
Objectives: The role of B cells in COVID‐19, beyond the production of specific antibodies against SARS-CoV-2, is still not well understood. Here, we describe the novel landscape of circulating double-negative (DN) CD27− IgD− B cells in COVID‐19 patients, representing a group of atypical and neglected subpopulations of this cell lineage. Methods: Using multiparametric flow cytometry, we determined DN B cell subset amounts from 91 COVID-19 patients, correlated those with cytokines, clinical and laboratory parameters, and segregated them by principal components analysis. Results: We detected significant increments in the DN2 and DN3 B cell subsets, while we found a relevant decrease in the DN1 B cell subpopulation, according to disease severity and patient outcomes. These DN cell numbers also appeared to correlate with pro- or anti-inflammatory signatures, respectively, and contributed to the segregation of the patients into disease severity groups. Conclusion: This study provides insights into DN B cell subsets' potential role in immune responses against SARS‐CoV‐2, particularly linked to the severity of COVID‐19.
- Subjects
B cells; SARS-CoV-2; COVID-19; PRINCIPAL components analysis
- Publication
Inflammation Research, 2022, Vol 71, Issue 1, p131
- ISSN
1023-3830
- Publication type
Article
- DOI
10.1007/s00011-021-01525-3