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- Title
Testicular Adrenal Rest Tumors in Congenital Adrenal Hyperplasia: Study of a Cohort of Patients from a Single Italian Center.
- Authors
Ortolano, Rita; Cassio, Alessandra; Alqaisi, Randa S.; Candela, Egidio; Di Natale, Valeria; Assirelli, Valentina; Bernardini, Luca; Bortolamedi, Elisa; Cantarelli, Erika; Corcioni, Beniamino; Renzulli, Matteo; Balsamo, Antonio; Baronio, Federico
- Abstract
Testicular adrenal rest tumors (TARTs) are a common complication in male patients with congenital adrenal hyperplasia (CAH). The aim of our cross-sectional cohort study is to estimate the frequency of TARTs with the correlation of genotype and disease control on tumor development. Thirty-five male patients, aged 14–26 years, were included in the study, all followed by the same center of pediatric endocrinology in Bologna. We studied genotypes, hormonal profiles at different time intervals and testicular ultrasound. A logistic regression model with multivariant analysis was developed for the statistical analysis. TARTs were detected in 31.4% of the cases, 90.9% of them had a classic form with salt wasting, while 9.1% had a non-classic form. Additionally, a significant correlation between the incidence of TARTs and severity of genotype was detected. Patients with TARTs had markedly worse metabolic control on average (p = 0.027), reflected by high ACTH, 17OH progesterone, and overall delta4-androstenedione. In conclusion, a screening tool is mandatory, especially (but not exclusively) in patients with the most severe forms of CAH and poor endocrine control of the disease.
- Subjects
ITALY; ADRENOGENITAL syndrome; ADRENAL diseases; DISEASE progression; RESEARCH; ENDOCRINOLOGY; STATISTICS; ULTRASONIC imaging; PROGESTERONE; TESTICULAR diseases; CROSS-sectional method; MULTIPLE regression analysis; MULTIVARIATE analysis; SEX differentiation disorders; PEDIATRICS; RETROSPECTIVE studies; FISHER exact test; MANN Whitney U Test; RISK assessment; T-test (Statistics); DESCRIPTIVE statistics; CHI-squared test; STATISTICAL correlation; ANDROSTENEDIONE; DATA analysis software; GENETIC profile; LONGITUDINAL method; DISEASE risk factors; DISEASE complications
- Publication
Children, 2023, Vol 10, Issue 9, p1457
- ISSN
2227-9067
- Publication type
Article
- DOI
10.3390/children10091457