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- Title
Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses.
- Authors
Baba, Yoshihiro; Nishida, Keigo; Fujii, Yoko; Hirano, Toshio; Hikida, Masaki; Kurosaki, Tomohiro
- Abstract
Mast cells have key functions as effectors of immunoglobulin E–mediated allergic inflammatory diseases. Allergen stimulation induces Ca2+ influx and elicits the secretion of inflammatory mediators from mast cells. Here we show that the Ca2+-binding endoplasmic reticulum protein STIM1 is critical to mast cell function. STIM1-deficient fetal liver–derived mast cells had impaired Ca2+ influx mediated by the high-affinity immunoglobulin E receptor FcεRI and activation of the transcription factors NF-κB and NFAT. Mast cells lacking STIM1 also had much less degranulation and cytokine production after FcεRI stimulation. In addition, alterations in STIM1 expression affected the sensitivity of immunoglobulin E–mediated immediate-phase anaphylactic responses in vivo. Thus, STIM1 is key in promoting the Ca2+ influx that is essential for FcεRI-mediated mast cell activation and anaphylaxis.
- Publication
Nature Immunology, 2008, Vol 9, Issue 1, p81
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni1546