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- Title
Acute inhalation co‐exposure to 1,2‐dichloropropane and dichloromethane cause liver damage by inhibiting mitochondrial respiration and defense ability in mice.
- Authors
Wang, Hufei; Chen, Jiamin; Suda, Megumi; Yanagiba, Yukie; Weng, Zuquan; Wang, Rui‐Sheng
- Abstract
1,2‐Dichloropropane (1,2‐DCP) is used as an industrial solvent, insecticide fumigant and household dry cleaning product. Carcinogenicity caused by long‐term exposure to 1,2‐DCP is well established. However, the possible liver damage and related toxic mechanisms associated with acute inhalation exposure to 1,2‐DCP are rarely reported. In this study, we investigated the effects of individual and combined exposure to 1,2‐DCP and dichloromethane (DCM) on mice liver. The results showed that 1,2‐DCP significantly caused liver necrosis, possibly due to 1,2‐DCP‐induced inhibition of the mitochondrial respiratory chain complex I‐IV activities, resulting in mitochondrial dysfunction and extreme ATP consumption. Moreover, 1,2‐DCP also decreased mitochondrial defense ability by inhibiting the mitochondrial glutathione S‐transferase 1 (MGST1) activity, further aggravating liver damage. Additionally, we found that DCM co‐exposure potentially enhanced 1,2‐DCP toxicity. Our findings suggest that inhibition of mitochondrial function and MGST1 activity play critical roles in modulating 1,2‐DCP‐induced liver damage. Furthermore, our results contribute to study the new mechanism of mitochondria‐dominated signaling pathways underlying liver injury induced by 1,2‐DCP and DCM. In this study, we investigated the effects of individual and combined acute inhalation exposure to 1,2‐dichloropropane (1,2‐DCP) and dichloromethane (DCM) on mice liver. The results showed that 1,2‐DCP significantly caused liver necrosis, possibly due to 1,2‐DCP‐induced inhibition of the mitochondrial respiratory chain complex I‐IV activities, inhibiting the mitochondrial MGST1 activity, resulting in mitochondrial dysfunction and extreme ATP consumption. DCM co‐exposure potentially enhanced 1,2‐DCP toxicity.
- Subjects
DICHLOROPROPANE; DICHLOROMETHANE; LIVER injuries; MITOCHONDRIAL pathology; CELL respiration
- Publication
Journal of Applied Toxicology, 2019, Vol 39, Issue 2, p260
- ISSN
0260-437X
- Publication type
Article
- DOI
10.1002/jat.3715