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- Title
Endotoksemi Şekillendirilmiş Ratlarda Marbofloksasin, Diklofenak Sodyum ve Metilprednizolonun Serum Biyokimyasal Değerler Üzerine Etkisi.
- Authors
ÖNER, Ahmet Cihat; ŞAHİN, Ali
- Abstract
Escherichia coli-derived lipopolysaccharide (LPS) has been used extensively as a model for septic shock and sepsis. In our study, it was aimed to induce experimental endotoxemia in rats by using LPS and the effects of marbofloxacin, diclofenac sodium and methylprednisolone on alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), blood urea nitrogen (BUN), creatinine, which are indirect indicators of organ insufficiency, were assessed. 186 rats were divided into 5 groups. Blood samples were obtained from control group at 0 h. To shape endotoxemia, LPS was administered at a dose of 4 mg/rat via intraperitonally (IP). Marbofloxacin (100 mg/kg, IP), diclofenac sodium (10 mg/kg, IP) and metylprednisolone (10 mg/kg, IP) were administered at dosage for the treatment of developing endotoxemia. Blood samples were collected under thiopental anesthesia at 1, 2, 4, 8, 12 and 24 h. They were analyzed biochemical levels. In the study, it was determined that serum ALP, ALT, AST, GGT, BUN and creatinine levels increased with LPS application (P<0.05) and the expected effect in sepsis was formed. As a result, LPS administration caused sepsis and it had several effects observed in the kidney and liver. It was concluded that in the treatment of sepsis, drugs other than methylprednisolone cannot be used alone, but combined application can be preferred.
- Subjects
SEPTIC shock; BLOOD urea nitrogen; ASPARTATE aminotransferase; ALKALINE phosphatase; SEPSIS; GAMMA-glutamyltransferase; ALANINE aminotransferase; ENDOTOXEMIA
- Publication
Van Veterinary Journal, 2021, Vol 32, Issue 3, p98
- ISSN
2149-3359
- Publication type
Article
- DOI
10.36483/vanvetj.948037