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- Title
Successful growth of fresh retinoblastoma cells in chorioallantoic membrane.
- Authors
Fialho, Silvia L.; Silvestrini, Bárbara R.; Vieira, Juliana; Paiva, Mayara R. B.; Silva, Luciana M.; Chahud, Fernando; Silva-Cunha, Armando; Correa, Zelia M.; Jorge, Rodrigo
- Abstract
The authors developed a retinoblastoma model using fresh harvested cells from an enucleated eye that were transplanted in chick embryos (chorioallantoic membrane model). The transplanted embryos were treated with escalating doses of Melphalan. This exploratory model was developed with the goal of testing drug sensitivity. Our findings suggest this tumor model could be employed to personalize treatment for patients with retinoblastoma, especially those with bilateral and more refractory disease.
- Publication
International Journal of Retina & Vitreous, 2020, Vol 6, Issue 1, p1
- ISSN
2056-9920
- Publication type
Letter
- DOI
10.1186/s40942-020-00236-x