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- Title
Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives.
- Authors
Jankovská, Dagmar; Jurčová, Nikol; Kubínová, Renata; Václavík, Jiří; Švajdlenka, Emil; Mascellani, Anna; Maršík, Petr; Bouzková, Kateřina; Malaník, Milan
- Abstract
Five putrescine and spermidine derivatives (1–5) together with five rotenoids (6–10) were isolated from a methanolic extract of the flowers of A. fruticosa that displayed promising inhibition of 76.0 ± 1.9% for AChE and 90.0 ± 4.0% for BuChE at a concentration of 1 mg/mL. Although the anticholinesterase activities of the isolated compounds did not reach that of galantamine, molecular docking revealed that all-trans-tri-p-coumaroylspermidine and trans-trans-cis-tri-p-coumaroylspermidine showed binding poses mimicking the known inhibitor galantamine and thus could serve as model molecules in future searches for new AChE and BuChE inhibitors.
- Subjects
SPERMIDINE; PUTRESCINE; MOLECULAR docking; GALANTHAMINE; FLOWERS; POLYAMINES; BIOGENIC amines
- Publication
Plants (2223-7747), 2024, Vol 13, Issue 9, p1181
- ISSN
2223-7747
- Publication type
Article
- DOI
10.3390/plants13091181